请帮我翻译一下这段话！

Question

3.Metformin has a long track record of efficacy, minimal weight gain and low risk of hypoglycemia. Despite the potential benefits of metformin, some patients cannot tolerate the gastroin-testinal (GI) side effects associated with this drug [3].Insulin secretagogues, such as sulfonylureas and megli-
tinides, are also frequently used early in the treatment of a patient with diabetes as they generally elicit clinical efficacy in the short term; however, they have been noted to fail to maintain efficacy over time. While the secretagogues are targeting one of the component defects of T2DM by stimulating endogenous insulin secretion, they are often associated with hypoglycemia and weight gain, thus limiting their use. Thiazolidinediones target a third aspect of the physiologic defects of the diabetic patient by increasing insulin sensitivity in the periphery and have shown sustained durability of effect and infrequent incidence of hypoglycemia; however, they, too, have side effects that possibly limit their use, such as edema and weight gain

Answer 1

3、二甲双胍具有良好的疗效，最小的体重增加和低血糖风险。尽管二甲双胍的潜在利益，一些患者不能耐受胃肠道（GI）与药物相关的副作用[ 3 ]。胰岛素促泌剂，如磺脲类和megli - tinides，也经常用于糖尿病患者的早期治疗通常引起临床疗效在短期内；然而，他们已经注意到不能维持疗效时间。而分泌的目标是一个糖尿病的成分通过刺激内源性胰岛素分泌缺陷，他们往往是低血糖和体重增加有关，从而限制了它们的使用。噻唑烷二酮类目标三分之一方面的糖尿病病人的生理缺陷，通过增加外围胰岛素敏感性和显示和低血糖罕见的发病率的影响持续的耐久性；然而，他们也有副作用，可能会限制其使用，如水肿和体重增加

追问

你用什么烦的?好快啊 ！

Answer 2

照明的灯泡靠谱