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This article will introduce and review a new potential pharmacologic agent, imeglimin, comparing its
basic and clinical activity to that of other widely used medications.In general, pharmacologic therapy includes not only initial antihyperglycemic agents, but also more intensive approaches to glycemic control over time, often requiring multiple medications with synergistic mechanisms of action [4]. At first glance it seems that there are sufficient numbers of therapeutic classes of agents to treat T2DM,with each class varying in mechanism, safety, efficacy and route of administration; however, few drugs target all three of the main defects associated with T2DM, which is why complex medication regimens are often required to achieve glycemic control. Metformin is widely recognized as first- line therapy in multiple treatment algorithms, and is known to work primarily by limiting hepatic glucose production, one of the key defects of T2DM

This article will introduce and review a new potential pharmacologic agent, imeglimin, comparing its
本文将介绍和分析一个潜在的新的药物制剂,临床,比较
basic and clinical activity to that of other widely used medications.In general, pharmacologic therapy includes not only initial antihyperglycemic agents, but also more intensive approaches to glycemic control over time, often requiring multiple medications with synergistic mechanisms of action [4]. At first glance it seems that there are sufficient numbers of therapeutic classes of agents to treat T2DM,with each class varying in mechanism, safety, efficacy and route of administration; however, few drugs target all three of the main defects associated with T2DM, which is why complex medication regimens are often required to achieve glycemic control. Metformin is widely recognized as first- line therapy in multiple treatment algorithms, and is known to work primarily by limiting hepatic glucose production, one of the key defects of T2DM
基础与临床,其他常用药物的活动。一般来说,药物治疗不仅包括初始的降糖药物,而且随着时间的推移血糖控制更密集的方法,往往需要多种药物的作用[ 4 ]协同机制。乍一看,似乎有足够数量的药物治疗T2DM治疗类,每类不同的机制,安全,和给药途径的效果;然而,一些药物目标三与糖尿病有关的主要缺陷,这就是为什么复杂的药物治疗方案往往需要达到血糖控制。二甲双胍是目前公认的在多个处理算法的第一线治疗,是已知的工作主要是通过限制肝脏葡萄糖的产生,其中T2DM的主要缺陷追问

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